Peptides represent one of the fastest growing segments of the pharmaceutical industry. This can be attributed to the rapidly growing pipeline of peptide-based therapeutics, driven by the need for effective and personalized pharmacological interventions.

The global peptide synthesis market size is estimated to grow from USD 2.8 billion in 2024 to USD 5.1 billion by 2035, representing a CAGR of 5.5% during the forecast period 2024-2035.

Since peptide-based drugs are being used progressively for the treatment of various diseases, the demand is indubitably rising and expected to grow at annualized rate of over 7% in the near future

Major proportion of the current demand for peptide therapeutics contract API manufacturing is from solid phase synthesis (49%), followed by liquid phase synthesis (36%). It is worth noting that this trend is unlikely to change in the future as well. In 2035, solid phase peptide synthesis is anticipated to capture around 51% of the overall demand. This can be attributed to a steady shift from liquid to solid phase peptide synthesis due to multiple advantages offered by SPPS, some of which include rapid peptide formation, easy removal of excess reagents, and compatibility with automated synthesis technologies.

The installed global peptide synthesis capacity is spread across various geographies; large players account for around 90% of the total capacity Owing to several factors, including globalization and introduction of political and regulatory reforms, advanced contract manufacturing services for peptide synthesis are no longer confined to the developed geographies alone. Currently, several players in emerging geographies, such as those offer high quality contract manufacturing services for biopharmaceuticals, along with providing lucrative cost benefits. Maximum capacity (335,048 liters) for the peptide synthesis is presently installed in facilities of large players. This can be attributed to the fact that peptide synthesis require skilled manpower and specialized facilities which needs huge capital investments that are usually available with large companies. This is followed by capacity available with mid-sized players, contributing to 9% of the overall peptide synthesis  capacity.

Our proprietary total cost of ownership model offers an informed estimate of capital and operational expenses associated with the establishment and maintenance of a contract manufacturing facility, over a span of 20 years. Over the past few years, the continuous rise in demand for peptide-base drugs has led to a surge in outsourcing of key operations in the peptide synthesis industry. Recent years have also witnessed the emergence of a large number of highly qualified CMOs that assist players in manufacturing of proprietary peptide API to expedite the overall workflow. However, establishment of advanced facilities is often a very expensive initiative, considering the numerous purchase costs, as well as expenses incurred while installing, deploying, using, upgrading and maintaining the asset. It is worth mentioning that OPEX is an ongoing cost that is incurred in order to keep a technology, product or a system running; it includes expenses related to administrative operations, research and development, salaries of employees, raw materials, and inventories. Therefore, it is anticipated to increase over the next two decades, due to rising cost incurred for maintenance of a facility.

Research Methodology

Our analysts have performed an accurate examination of the various aspects of the global market leveraging avant-garde primary and secondary sources of data collection. The report has gathered the necessary data and information from several reliable sources. Additionally, the report offers many strategic recommendations for companies involved in this ever-growing business sector to help them attain a competitive edge in the Peptide Synthesis Market. 

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